CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee Regeneration

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee Regeneration

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News Editor
2026-06-27 12:31:20
In a Galaxy interview, Binance founder CZ shared his views on crypto market cycles, noting the current 50% pullback is milder than previous 80% drawdowns, and each cycle starts from a higher base. He predicts deep integration between crypto and traditional finance, with better leverage control industry-wide. CZ revealed Yzi Labs' investment allocation: 70% crypto, 20% AI, 10% biotech, including an artificial womb company and a knee cartilage regeneration project. He praised Hyperliquid's innovation and highlighted prediction markets like Polymarket. CZ also warned of AI's existential risks while emphasizing crypto's relative safety and potential to reshape global finance.
CZBinanceCrypto Market CyclesInvestment PortfolioArtificial IntelligenceBiotechnologyPrediction MarketsHyperliquidMacro Trends

Market Cycles: Higher Bottoms, Better Leverage Control

CZ believes the four-year crypto cycle remains valid, with the current 50% price pullback significantly milder than the 80% corrections of earlier cycles. He noted that after the 2022 Luna collapse and FTX bankruptcy, Bitcoin bottomed at $16,000; today's price is 4-5 times higher, and each cycle's starting point is elevated. Technically, previous highs (like $60,000) often become future support levels. Positive structural changes include: sovereign adoption of Bitcoin, institutional participation (BlackRock ETFs, BNB ETF listings), developer activity returning to the US, multiple countries issuing stablecoins, and RWA access (SPCX, Pre-IPO tokens) on Binance. No major institution has approached bankruptcy in the past six months, and industry leverage is better managed — some high-yield stablecoin products exist but are small relative to market size, a constructive sign.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Integration of Crypto & TradFi: Coexistence of Centralized and Decentralized

CZ emphasized that crypto is not a separate industry but a new tool enabling faster, cheaper, more transparent financial transactions. Traditional finance can use blockchain, and crypto companies can offer lending, savings, stock trading, and payments — often with fiat on/off ramps. The line will blur into a single fintech sector. Regarding centralization vs. decentralization, he argued that any platform or team inherently has centralized elements due to human network effects. A decentralized world should accommodate centralized participants if they provide low-cost, secure, high-quality services, attracting users and creating network effects — even potential monopolies. However, monopolistic abuse tends to be self-correcting over time. CZ remains a strong supporter of decentralization, believing technology will push more tools toward that direction.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Blockchain Diversity: National Chains and User Choice

The spirit of decentralization allows anyone to build their own blockchain, not forced onto ETH or BNB. Users ultimately choose chains based on cost, security, and ease of use. CZ mentioned discussions with leaders of multiple countries who desire national blockchains but struggle with relinquishing monetary control. For large countries like the US, if Wall Street giants use one or two private blockchains with trillions in value, retail might be excluded — but that could still be a meaningful enterprise internet. Forcing everyone to use Bitcoin alone is not true decentralization.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Perpetual Futures & Liquidity: CME Entry is Positive

Perpetual futures were pioneered by BitMEX in 2014; Binance launched in 2019. Binance offers the best liquidity and pricing due to its large user base. Now CME and other traditional exchanges offer crypto futures, serving US institutions and adding liquidity to the entire market, benefiting consumers. CZ predicted that foreign exchange trading will also migrate on-chain. Binance's user base is globally dispersed, enabling people worldwide to buy foreign stocks and government bonds, improving liquidity and reducing geopolitical tensions.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Hyperliquid & Prediction Markets: Innovative Niches

CZ finds Hyperliquid interesting — its founder Jeff participated in early Yzi Labs incubation. Hyperliquid occupies a niche Binance cannot compete in: no KYC, claims of decentralization (though significant control remains), and genuine technical innovation. For prediction markets, Polymarket and Kalshi have US licenses; CFTC chair is supportive despite some state opposition. CZ believes prediction markets provide price discovery and liquidity, expecting 100-1000 projects to emerge, most doing responsible execution — good for consumers and the industry.

Technology Development: Return to L1, Upgrade Timing

Now free from exchange operations, CZ spends more time with BNB Chain developers. He advises major upgrades during bear markets, not bull runs. The next BNB Chain version will be faster, cheaper, and offer more privacy controls. He commented that BASE pays more in OP licensing fees than its actual L1 costs; Vitalik recognized L2s don't help L1, and after Ether's decline, he refocused on L1 scaling. CZ believes future belongs to L1, though faster L1 speeds may increase demand leading to new L2 iterations — a recurring L1-L2 cycle.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Investment Philosophy: 70% Crypto, 20% AI, 10% Biotech — Artificial Womb & Knee Regeneration Backed

Yzi Labs' portfolio is roughly 70% crypto, 20% AI, 10% biotech. CZ prioritizes impact over returns: investing a billion dollars in a cancer cure that saves millions, even if the company makes no profit, would make him happy. Early-stage projects carry high failure rates. Beyond crypto, they've invested in an artificial womb company (tested on mice, human applications 5-10 years away) and a knee cartilage regeneration technology using 3D-printed scaffolds to stimulate growth (early human trials). Biotech excites him the most.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Artificial Intelligence: Heavy Usage but Existential Risks

CZ uses multiple AI apps: OpenAI, Anthropic/Claude, Deepseek, Kimi — choosing by task. US models are more precise; Chinese models are good but less comprehensive. He warned that AI requires careful regulation: it can hack computers, design nuclear weapons, and if uncontrolled, could destroy civilization. Crypto, by contrast, cannot destroy civilization and facilitates global trade. He noted hot money flowing into AI stocks but observed that people trade AI stocks on crypto exchanges, and AI actually contributes to crypto trading volume. He emphasized that blockchain is API-friendly for AI, and the three — blockchain, AI, internet — will collaboratively build better financial systems.

CZ In-Depth on Crypto Cycles, AI & Biotech Investment: 70% Crypto, 20% AI, 10% Biotech, Backed Artificial Womb and Knee

Conclusion: Crypto Will Not Die

CZ reiterated that crypto will become a massive industry, with stronger conviction than ever. Though capital flows toward AI, it will ultimately settle on-chain. He called for upgrading the existing financial system to accommodate the age of AI and blockchain.

This article was originally published by Bit.Fan. For more cryptocurrency news and market insights, visit www.bit.fan.
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