Manchester City beat Ipswich Town 3-2 to go six points clear, as Enzo Maresca became the first Premier League manager to win his opening seven games in charge.
Manchester United drew 1-1 with Leeds United at Elland Road as their Premier League winless run reached five matches and their overall run stretched to six.
Udinese were beaten 3-0 by Lecce at the Bluenergy Stadium on Sunday 18 October, a fifth consecutive defeat that brought boos and protests at full time.
Roma beat Genoa 2-0, and Gian Piero Gasperini said the late collapse against Real Madrid drove the team's response.
Aston Villa beat Newcastle United 1-0 at St. James' Park as Johan Manzambi scored the only goal, with Unai Emery praising him after the match.
Liverpool beat Brentford 2-1 on Saturday, but injuries to Dominik Szoboszlai and Jeremie Frimpong raised concerns before Tuesday's home game with Villarreal.
La Liga announced its new delegates' committee on 16 October, with Barcelona returning and Real Madrid keeping a seat as tensions with Javier Tebas continued.
Valencia drew 0-0 with Athletic Club at the Mestalla, staying unbeaten but still without a win under Javier Aguirre.
